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免疫反应是工业毒物影响下机体早期改变的敏感性指标。本文研究了家免在二氯乙烷、三氯乙烷、四氯乙烷和五氯乙烷长期低浓度影响下特异性和非特异性免疫反应。实验用家免132只,体重2.3～3.5 kg,11组染毒,7组对照。动式吸入染毒每天3小时,每周6天,共8～10个月;浓度分别为2、10、100 mg/m~3。染毒后1.5个月、4.5～5个月、7.5～8个月三次皮下注射1 ml。15亿经热处理未灭活的肠伤寒疫苗O-901型悬浮液。测定总抗体的滴定度,和7S-肠伤寒O抗体量。用纸上电泳法分析清蛋白的组成和泳动度。并测定非特异性免疫的溶血素。结果:抗体的生长量取决于毒物的种类、浓度和接触时间。
Immune response is a sensitive indicator of early changes in the body under the influence of industrial toxicants. In this paper, we investigated the specific and nonspecific immune responses of home-stay under the influence of long-term low concentrations of dichloroethane, trichloroethane, tetrachloroethane and pentachloroethane. Experimental users were 132, body weight 2.3 ~ 3.5 kg, 11 groups of exposure, 7 control group. Dynamic inhalation exposure 3 hours a day, 6 days a week, a total of 8 to 10 months; concentrations were 2,10,100 mg / m ~ 3. 1.5 months after exposure, 4.5 to 5 months, 7.5 to 8 months subcutaneous injection of 1 ml three times. 1.5 billion heat-treated non-inactivated Salmonella typhimurium vaccine O-901 suspension. The titer of the total antibody and the amount of 7S-enterhalic-0 antibody were determined. The composition and mobility of albumin were analyzed by paper electrophoresis. And non-specifically immunized hemolysin was determined. Results: The amount of antibody growth depends on the type of poison, the concentration and the contact time.