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目的FOLFOX6方案治疗晚期胃癌的疗效和毒性。方法晚期胃癌患者40例,给予奥沙利铂(LOHP)100 mg/m2,静脉滴注2 h,第1天;亚叶酸钙(CF)200 mg/m2,静脉滴注2 h,第1天;随后氟尿嘧啶(5-Fu)400 mg/m2,静脉快速冲入,第1天;5-Fu 2400 mg/m2,静脉持续滴注46 h,每2周为1周期。至少3周期后评价疗效。结果全组患者40例,可评价疗效40例,完全缓解1例,部分缓解15例,稳定21例,进展3例,总有效率40.0%。毒副作用主要是骨髓抑制、消化道反应以及神经毒性,无化疗相关死亡。结论FOLFOX6方案治疗晚期胃癌疗效肯定,毒副作用能耐受。
Objective FOLFOX6 regimen for the treatment of advanced gastric cancer efficacy and toxicity. Methods Forty patients with advanced gastric cancer were treated with 100 mg / m2 oxaliplatin (LOHP) for 2 h on the first day, 200 mg / m2 leucovorin (CF) ; Followed by 5-FU fluorouracil 400 mg / m2, rapid intravenous infusions on day 1; 5-Fu 2400 mg / m2 intravenous drip for 46 h, every 2 weeks for 1 cycle. Evaluation of efficacy after at least 3 cycles. Results The whole group of 40 patients, the evaluation of 40 cases of efficacy, complete remission in 1 case, partial remission in 15 cases, stable in 21 cases, 3 cases of progress, the total efficiency of 40.0%. Toxic side effects are mainly myelosuppression, gastrointestinal reactions and neurotoxicity, without chemotherapy-related deaths. Conclusion The FOLFOX6 regimen is effective in treating advanced gastric cancer with tolerable side effects.