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目的:探讨泻肺活血通腑中药汤剂联合西药对慢性阻塞性肺疾病急性加重期(AECOPD)的治疗效果。方法:将120例慢性阻塞性肺疾病患者随机分为2组,观察组60例患者采用常规西药进行治疗,对照组60例患者采用泻肺活血通腑中药汤剂联合西药进行治疗。观察2组临床疗效,治疗前后血氧分压(Pa O2)、二氧化碳分压(Pa CO2)以及肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)、C-反应蛋白(CRP)等指标。结果:治疗后,观察组患者的Pa O2、Pa CO2有显著改善,与对照组比较,差异有显著性意义(P<0.05);观察组患者的TNF-α和CRP均有明显改善,2组比较,差异有显著性意义(P<0.05)。结论:泻肺活血通腑中药联合西药治疗AECOPD临床疗效显著,可促进了患者动脉血气相关指标的恢复,缓解病情。
Objective: To investigate the therapeutic effect of Xiefei Huoxue Tongfu decoction combined with western medicine on acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: 120 patients with chronic obstructive pulmonary disease were randomly divided into 2 groups. 60 patients in the observation group were treated with conventional western medicine. 60 patients in the control group were treated with Xiezuo Huoxue Tongfu Chinese herbal decoction combined with Western medicine. The clinical curative effect was observed in two groups. PaO2, PaCO2 and TNF-alpha, IL-8, C-reaction Protein (CRP) and other indicators. Results: After treatment, PaO2 and PaCO2 in the observation group were significantly improved compared with the control group, the difference was significant (P <0.05); TNF-α and CRP in the observation group were significantly improved, two groups The difference was significant (P <0.05). Conclusion: The clinical efficacy of Xiepi Huoxue Tongfu Chinese herbs combined with Western medicine in the treatment of AECOPD is significant, which can promote the recovery of arterial blood gas related indicators and relieve the disease.