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目的研究肺癌中AGBL2蛋白的表达及其临床意义,以期能够为肺癌的治疗提供线索。方法应用免疫组化技术研究本溪市中心医院378例患者肺癌组织中的AGBL2蛋白的表达情况,并分析AGBL2蛋白表达与临床特征及预后之间的关系。结果经Spearman相关分析,AGBL2蛋白表达与淋巴结转移显著相关。Cox回归模型中,AGBL2可作为肺癌的独立预后因子。结论 AGBL2或可作为肺癌的预后指标及潜在治疗靶点。
Objective To study the expression of AGBL2 protein in lung cancer and its clinical significance in order to provide clues for the treatment of lung cancer. Methods Immunohistochemical technique was used to study the expression of AGBL2 protein in lung cancer tissues from 378 patients with Benxi Central Hospital. The relationship between AGBL2 protein expression and clinical features and prognosis was analyzed. Results Spearman correlation analysis showed that AGBL2 protein expression was significantly associated with lymph node metastasis. Cox regression model, AGBL2 lung cancer as an independent prognostic factor. Conclusion AGBL2 may be used as a prognostic indicator of lung cancer and a potential therapeutic target.