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本实验使用健康杂种家狗制成急性肾功能衰竭(ARF)模型,设对照组和治疗组,用益母草针剂作治疗药物,以肌酐(Cr)、尿素氮(BUN)、滤过钠排泄分数(FE_(Na))、肾血流量(RBF)及动物存活情况作为观察指标,研究益母草对狗缺血型ARF的治疗作用。实验结果表明除Cr外,上述指标两组差异均十分明显,证明益母草治疗狗缺血型初发期ARF具有显著效果,并对其作用机理作了初步讨论。
In this experiment, acute renal failure (ARF) models were made from healthy hybrid dogs. Controls and treatment groups were set up. Herba leucas injections were used as therapeutic drugs, and creatinine (Cr), urea nitrogen (BUN), and filtered sodium excretion scores ( FE_(Na)), renal blood flow (RBF), and animal survival were used as observational indicators to study the therapeutic effects of Leonurus on ischemic ARF in dogs. The experimental results showed that the difference between the two groups was significant except for Cr. It was proved that Herba Leonuri has significant effects on the treatment of ischemic-type ARF in dogs and its mechanism of action was discussed.