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探讨帕金森病 (PD)大鼠颈动脉体球细胞块移植后其行为学的变化。采用 6 -羟多巴胺 (6 - OHDA)损毁大鼠一侧黑质细胞制成 PD样大鼠模型 ,在右侧纹状体内分别移植入胚胎黑质和自、异体颈动脉体球细胞块 ,在移植后 2、 4、 8和 12周记录阿朴吗啡诱发大鼠的旋转行为 ,同步分析存活酪氨酸羟化酶 (TH)阳性细胞数目。结果 :在 12周时与胚胎中脑组织移植组比较 ,自、异体颈动脉体球细胞移植组大鼠旋转行为改善更为明显 ,存活 TH+细胞显著增多 (分别 P<0 .0 5 ) ,但自、异体颈动脉体球细胞移植组间比较差异无显著性。提示 :颈动脉体球细胞块移植后 PD大鼠行为学显著改善 ,效果优于胚胎中脑组织块的移植
To investigate the behavioral changes of the carotid globus pallidus (Parkinson’s disease) rats after block transplantation. PD - like rat model was induced by 6 - hydroxydopamine (6 - OHDA) damaging rat substantia nigra and was implanted into the embryonic substantia nigra and the carotid body block of carotid body in the right striatum. The rotation behavior of apomorphine-induced rats was recorded at 2, 4, 8 and 12 weeks after transplantation, and the number of surviving tyrosine hydroxylase (TH) positive cells was simultaneously analyzed. Results: Compared with embryonic mesencephalic tissue transplantation group at 12 weeks, the rotation behavior of autogenous and allogeneic carotid body cell transplantation group was more obvious and the survival TH + cells were significantly increased (P <0.05, respectively) There was no significant difference between the allogeneic carotid body balloon transplantation group. It is suggested that the behavioral improvement of PD rats after carotid body block transplantation is better than transplantation of embryonic midbrain tissue blocks