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本文初步探讨了小剂量呋喃唑酮对十二指肠溃疡(DU)的疗效及对幽门螺杆菌(Hp)清除率的作用。45例内镜证实的活动性DU患者随机分两组:Ⅰ组25例服呋喃唑酮10mg 日七次;Ⅱ组20例服次枸橼酸铋(迪乐,Denol)110mg日4次,均为6周疗程后复查内镜及Hp。资料证明两组在症状缓解、DU愈合率、溃疡面积缩小率以及Hp清除率等方面均无显著差别,取得满意疗效。作者提出小剂量呋喃唑酮治疗DU与次枸橼酸铋同样有效,同样清除Hp,取代常规剂量呋喃唑酮以减除其毒副反应,对慢性疾病似更为适宜。
This article initially discussed the effect of low-dose furazolidone on duodenal ulcer (DU) and the effect on Helicobacter pylori (Hp) clearance rate. Forty-five patients with active DU confirmed by endoscopy were divided into two groups at random: 25 patients in group Ⅰ received furazolidone 10 mg daily for seven times, and 20 patients in group Ⅱ took bismuth citrate 110 mg four times daily for 6 times Week after treatment review of endoscopy and Hp. Data show that the two groups in symptom relief, DU healing rate, ulcer area reduction rate and Hp clearance rate and other aspects were not significantly different, and achieved satisfactory results. The authors suggest that low-dose furazolidone treatment DU and bismuth sub-citrate are equally effective, the same clear Hp, to replace the conventional dose of furazolidone in order to reduce its toxic side effects, the chronic disease seems more appropriate.