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目的 观察氯沙坦对糖尿病肾病的治疗效果。方法 对 30例已确诊的糖尿病肾病患者用氯沙坦治疗 6周 ,观察治疗前后 2 4h尿微量白蛋白排泄率、尿 β2 微球蛋白、血肌酐、血尿素氮、胰岛素敏感性及血清钾的变化。结果 治疗后病人 2 4h尿微量白蛋白排泄率明显降低 (P <0 0 1) ,尿β2 微球蛋白有降低 ,血肌酐稍有上升 ,血尿素氮稍有下降 ,但意义不大( P>0 0 5 )。结论 氯沙坦治疗糖尿病肾病有一定疗效 ,且无明显副作用
Objective To observe the therapeutic effect of losartan on diabetic nephropathy. Methods 30 patients with diabetic nephropathy who were diagnosed were treated with losartan for 6 weeks. The urinary albumin excretion rate, urinary β2 microglobulin, serum creatinine, blood urea nitrogen, insulin sensitivity and serum potassium Variety. Results After treatment, urinary albumin excretion rate was significantly lower (P <0.01), urinary β2 microglobulin was decreased, serum creatinine slightly increased and blood urea nitrogen slightly decreased (P> 0 0 5). Conclusion Losartan treatment of diabetic nephropathy have a certain effect, and no obvious side effects