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为了了解多肿瘤抑制基因 P16 蛋白在肾癌中的表达 ,采用免疫组化 L SAB法测定了 68例肾癌组织和 6例癌旁正常肾组织中 P16 蛋白的表达。结果 6例癌旁正常肾组织 P16 蛋白呈强阳性表达 ,68例肾癌组织 P16 蛋白类丢失 39例 ( 5 7.4% )。 P16 蛋白的丢失与肾癌临床分期、病理分级相关 ,与肾癌细胞类型无关。认为 P16 蛋白的表达可作为估价肾癌恶性程度和判断预后的一个重要指标。
In order to understand the expression of multi-tumor suppressor gene P16 in renal cell carcinoma, the expression of P16 protein in 68 cases of renal cell carcinoma and 6 cases of adjacent normal renal tissues was detected by immunohistochemical L SAB method. Results The positive expression of P16 protein in 6 cases of adjacent normal renal tissues was strong, while in 39 cases of renal cell carcinoma, P16 protein was lost in 39 (5 7.4%) cases. P16 protein loss and renal cell carcinoma staging, pathological grade related to the type of renal cell carcinoma has nothing to do. P16 protein expression that can be used as a valuation of malignancy and prognosis of renal cancer is an important indicator.