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目的 探讨 6 0岁以上老年人短暂性脑缺血发作 (TIA)患者凝血纤溶系统的功能状态。方法 随机选出 TIA患者 6 0岁以上 30例 ,6 0岁以下 30例 (为对照组 ) ,采用双抗体夹心 EL ISA法测定血浆血小板颗粒膜糖蛋白 (GMP- 140 )和 D-二聚体 (DD)浓度。结果 老年 TIA组血浆 GMP- 140浓度低于对照组 (P<0 .0 5 ) ,但两组浓度均略高于正常值。老年 TIA组 DD浓度明显高于对照组 (P<0 .0 5 ) ,发病 3个月内随访 ,老年 TIA组中 6例发展成脑梗死 ,对照组有 2例 ,均为 DD增高者。结论 老年 TIA组患者体内凝血纤溶系统比较活跃 ,并且持续时间较长 ,故对老年人 TIA的治疗除给予抗血小板活化剂药物治疗外 ,还应适当给予降纤、抗纤溶药物治疗
Objective To investigate the functional status of coagulation and fibrinolytic system in patients with TIA over 60 years old. Methods Thirty patients with TIA and 30 patients under 60 years old were selected randomly as the control group. Plasma GAG-140 and D-dimer were measured by ELISA method. (DD) concentration. Results The plasma concentration of GMP-140 in the elderly TIA group was lower than that in the control group (P <0.05), but the concentration of GMP-140 in the elderly TIA group was slightly higher than the normal value. The concentration of DD in the elderly TIA group was significantly higher than that in the control group (P <0.05). Within 3 months after the onset of disease, 6 cases developed cerebral infarction in the TIA group and 2 cases in the control group. Conclusion In the elderly TIA group, the coagulation and fibrinolytic system in vivo is relatively active and has a long duration. Therefore, in addition to antiplatelet activator drug therapy, the treatment of elderly TIA should be appropriately given antifibrinolytic and antifibrinolytic drugs