【摘 要】
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The natural design for the generation and the fate of proteins in an organism could be as complicated as life itself.A protein is biosynthesized strictly accord
【机 构】
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Department of Neurochemistry, Inge Grundke-lqbal Research Floor, New York State Institute for Basic
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The natural design for the generation and the fate of proteins in an organism could be as complicated as life itself.A protein is biosynthesized strictly according to the message carried by the mRNA transcribed from its gene.However,when,where,what and how much a gene is expressed are regulated precisely and dynamically at multiple levels,including at transcription,mRNA maturation,alteative splicing,and translation levels.A newly synthesized protein often needs to be further modified and sorted posttranslationally for its optimal confirmation and function.When a protein reaches its life span,the senescent protein is degraded by protein degradation machinery involving the ubiquitin-proteosome system and lysosomes.Protein homeostasis is essential for maintaining the normal morphology and function of the cell.
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