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目的观察甲氨蝶呤联合米非司酮治疗输卵管妊娠的临床效果。方法将医院收治的输卵管妊娠患者73例作为研究对象,将其分为对照组36例和观察组37例。对照组采用甲氨蝶呤治疗,观察组采用甲氨蝶呤联合米非司酮治疗,观察2组患者的临床疗效、体征变化及不良反应发生率。结果观察组治疗总有效率为91.89%,高于对照组的72.22%(P<0.05);观察组包块消失及血β-h CG转阴用时均明显短于对照组(P<0.01);观察组不良反应发生率为2.70%,低于对照组的19.44%(P<0.05)。结论甲氨蝶呤联合米非司酮治疗输卵管妊娠效果显著,不良反应少。
Objective To observe the clinical effect of methotrexate combined with mifepristone in the treatment of tubal pregnancy. Methods Totally 73 patients with tubal pregnancy admitted to hospital were divided into control group (36 cases) and observation group (37 cases). The control group was treated with methotrexate. The observation group was treated with methotrexate combined with mifepristone. The clinical efficacy, signs and adverse reactions in the two groups were observed. Results The total effective rate of observation group was 91.89%, which was significantly higher than that of control group (72.22%, P <0.05). The disappearance of mass and blood β-h CG in the observation group were significantly shorter than those in the control group (P <0.01). The incidence of adverse reactions in the observation group was 2.70%, which was lower than that in the control group (19.44%, P <0.05). Conclusion Methotrexate combined with mifepristone treatment of tubal pregnancy significant effect, less adverse reactions.