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采用免疫胶体金标记技术和低温包埋与常规电镜观察相结合的方法,研究了EHF患者活检肝脏标本,首次发现肝细胞内的EHF病毒,证实病毒可侵袭肝实质细胞。在早期患者肝狄氏间隙内见到Ag-Ab复合物,认为早期患者体内也存在免疫复合物反应。同时发现以肝细胞膜、内质网、线粒体等膜性结构损伤为特征的细胞损害,证明了病毒对肝脏的直接损伤作用。由此对EHF的发病机理提出了新的学说。
Immune colloid gold labeling technology and low temperature embedding and conventional electron microscopy combined method of biopsy of EHF patients with liver specimens, the first discovery of intrahepatic EHF virus, confirmed that the virus can attack hepatic parenchymal cells. The Ag-Ab complex is seen in the Liver Dick’s gap in early patients, suggesting that there is also an immune complex response in early-stage patients. At the same time, it was found that the cell damage characterized by membranous damage such as hepatocyte membrane, endoplasmic reticulum, mitochondria and so on, proved the direct damage of the virus to the liver. Thus put forward a new theory of the pathogenesis of EHF.