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糖原磷酸化酶具有许多特性,并已证明它是一种可表示心肌损伤的酶。这种酶以蛋白质-糖原复合物的形式存在于肌肉中。缺氧时,由于糖原分解,它由微粒状态转变成可溶的形式。在心肌中有三种磷酸化酶同功酶,Davis等分别命名为磷酸化酶同功酶Ⅰ、Ⅱ和Ⅲ。在骨骼肌中仅含有磷酸化酶同功酶Ⅲ。在人的心肌中较大一部分磷酸化酶活性来自同功酶Ⅰ。因此,通过测定磷酸化酶同功酶Ⅰ和Ⅲ,可以鉴别心肌和骨骼肌的磷酸化酶。
Glycogen phosphorylase has many properties and has been shown to be an enzyme that can represent myocardial damage. This enzyme exists as a protein-glycogen complex in the muscle. In hypoxia, it changes from a particulate state to a soluble form due to glycogen breakdown. There are three phosphorylase isozymes in the myocardium, and Davis et al. Are named phosphorylase isoenzymes I, II and III, respectively. In skeletal muscle contains only phosphorylase isoenzyme Ⅲ. A large part of the phosphorylase activity in human myocardium comes from isoenzyme I. Therefore, phosphorylase in myocardium and skeletal muscle can be identified by measuring phosphorylase isoenzymes I and III.