戊型肝炎病毒是散发性和流行性病毒性肝炎的重要病原之一。中国一般人群中约1/3人曾感染过该病毒,主要侵犯中老年人群。虽然戊型肝炎为自限性疾病,一般不发展成慢性肝炎,但其病死率相对较高。戊型肝炎病毒至少有4个基因型,中国流行的是基因1型和4型,基因3型和4型主要见于猪,为人畜共患性疾病。中国自主研制的重组戊型肝炎疫苗(HEV239)随机双盲安慰剂对照Ⅲ期临床试验结果表明,该疫苗在我国普通人群中可有效预防戊型肝炎,且耐受性良好,有望用于高危人群的预防。 Hepatitis E virus is one of the important pathogens of sporadic and epidemic viral hepatitis. About 1/3 of China’s general population have been infected with the virus, mainly in the elderly. Although hepatitis E is a self-limiting disease, it generally does not develop into chronic hepatitis, but its mortality is relatively high. Hepatitis E virus has at least 4 genotypes. Genotypes 1 and 4 are endemic in China. Genes 3 and 4 are mainly found in pigs, which are zoonotic diseases. The randomized, double-blind, placebo-controlled phase III clinical trial of recombinant HEV vaccine (HEV239) independently developed in China showed that the vaccine can effectively prevent hepatitis E in the general population in China and is well tolerated and is expected to be used in high-risk groups Prevention.