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子宫内膜息肉(EMP)是引起异常子宫出血的常见疾患,有一定的恶变率,而且治疗后复发者相当多。随着生殖医学的发展和宫腔镜技术的推广应用,子宫内膜息肉的诊断水平得到很大提高,但发病机制及其与子宫内膜癌的内在关系尚不清楚,目前认为可能与细胞凋亡调控失常有关。细胞凋亡不仅与有机体的生殖发育、免疫老化等生理过程有关,还与许多增殖性疾病和肿瘤的发生发展密切相关,其在分子水平受多种癌基因与抑癌基因调控。综述不同凋亡相关基因如bcl-2,p63,PTEN,ras等在子宫内膜息肉的发生发展、恶变及治疗中的作用,指导临床合理诊治子宫内膜息肉。
Endometrial polyps (EMP) is a common cause of abnormal uterine bleeding, a certain rate of malignancy, and relapse after treatment quite a lot. With the development of reproductive medicine and the popularization and application of hysteroscopy, the diagnostic value of endometrial polyps has been greatly improved, but the pathogenesis and its relationship with endometrial cancer is not yet clear, and is currently believed that the possibility of apoptosis Death regulation disorders related. Apoptosis is not only related to the reproductive development of organism, immune aging and other physiological processes, but also with many proliferative diseases and the occurrence and development of tumors is closely related to its molecular level by a variety of oncogenes and tumor suppressor genes. To summarize the roles of different apoptosis-related genes such as bcl-2, p63, PTEN and ras in the development, malignant transformation and treatment of endometrial polyps, and to guide clinical diagnosis and treatment of endometrial polyps.