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目的利用Meta分析揭示VEGF-C和VEGFR-3在胃癌患者中的表达规律,探讨其表达与胃癌临床特点和预后之间的关系,为胃癌个体化治疗提供依据。方法收集过去10年国内发表的关于VEGF-C、VEGFR-3和胃癌的文献,按照一定的入选和排除标准选出研究方法类似的文献,汇总原始数据后进行Meta分析。结果(1)胃癌组织VEGF-C阳性率为40.7%～73.6%,VEGFR-3的阳性率为35.4%～61.6%,与正常胃黏膜相比都有明显增高。并且,VEGF-C的表达与VEGFR-3表达相关。(2)VEGF-C阳性与胃癌浸润浆膜、淋巴结转移、TNM分期高、分化程度低和5年生存率低有关。(3)VEGFR-3与胃癌浸润浆膜、淋巴结转移和分化程度低有关,与临床分期和5年生存率不相关。(4)患者年龄、性别、肿瘤部位和鲍曼分型与VEGF-C和VEGFR-3表达无关。结论VEGF-C和VEGFR-3的表达反映了胃癌淋巴结转移的生物学特性,可作为不良预后的预测因素,并提供了新的治疗靶点。
Objective To detect the expression of VEGF-C and VEGFR-3 in gastric cancer by Meta-analysis, and to explore the relationship between the expression of VEGF-C and clinical features and prognosis of gastric cancer and to provide a basis for individualized treatment of gastric cancer. Methods The literature about VEGF-C, VEGFR-3 and gastric cancer published in the past 10 years in our country was collected. According to certain criteria of inclusion and exclusion, the research methods were selected, and the original data were collected for meta-analysis. Results (1) The positive rate of VEGF-C in gastric cancer tissues was 40.7% -73.6%, the positive rate of VEGFR-3 was 35.4% -61.6%, which was significantly higher than that in normal gastric mucosa. Moreover, the expression of VEGF-C correlates with VEGFR-3 expression. (2) VEGF-C positivity is associated with gastric serosal invasion serosa, lymph node metastasis, high TNM stage, low differentiation and low 5-year survival rate. (3) VEGFR-3 is related to the infiltration of serosa, lymph node metastasis and poorly differentiated gastric cancer, which is not related to clinical stage and 5-year survival rate. (4) The age, sex, tumor location and Bowman’s classification had no relation with the expression of VEGF-C and VEGFR-3. Conclusions The expressions of VEGF-C and VEGFR-3 reflect the biological characteristics of lymph node metastasis of gastric cancer, which may be used as predictors of poor prognosis and provide new therapeutic targets.