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目的探讨常见血液肿瘤患者凝血指标的变化。方法 100例血液肿瘤患者作为研究组,选取同期体检健康者100例作为对照组。抽取两组患者的血液样本,对比凝血酶原时间(PT)、凝血活酶时间(APTT)、凝血酶时间(TT)、血小板计数(PLT)、纤维蛋白原(FIB)以及D-二聚体(DD)等凝血指标的检查结果。结果研究组患者的PT(13.34±2.1)s、APTT(33.8±7.1)s、DD(6.12±1.81)mg/L以及FIB(3.2±1.1)g/L较对照组的(10.3±0.6)s、(25.5±2.8)s、(0.41±0.03)mg/L、(2.4±0.5)g/L明显升高,而PLT(183.1±151.2)109×L明显低于对照组(245.8±55.7)109×L(P<0.05),TT结果对比差异无统计学意义(P>0.05)。结论常见血液肿瘤患者伴有不同程度的血液高凝,通过监测血凝指标可及时的发现是否形成血栓,尽早接受治疗。
Objective To investigate the changes of coagulation indexes in patients with common hematological tumors. Methods One hundred patients with hematological malignancies were selected as the research group, and 100 healthy subjects were selected as the control group. The blood samples of two groups of patients were collected and compared with PT, APTT, TT, PLT, fibrinogen (FIB) and D-dimer (DD) and other indicators of blood coagulation test results. Results Compared with the control group, PT (13.34 ± 2.1) s, APTT (33.8 ± 7.1) s, DD (6.12 ± 1.81) mg / L and FIB , (25.5 ± 2.8) s, (0.41 ± 0.03) mg / L and (2.4 ± 0.5) g / L respectively, while the PLT (183.1 ± 151.2) 109 × L was significantly lower than that of the control group (245.8 ± 55.7) × L (P <0.05), but there was no significant difference in TT (P> 0.05). Conclusions Common hematological malignancies are associated with varying degrees of hypercoagulability. Thromboembolic indicators can be used to detect thrombosis in time and receive early treatment.