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目的 研究抑癌基因 p16与肾盂癌病理分级、临床分期及预后的关系 .方法 应用免疫组织化学对 40例肾盂癌标本中抑癌基因 p16的表达进行检测 .结果 40例肾盂癌组织中 p16基因表达的阳性率为 5 2 .5 % ,其阳性率随肾盂癌病理分级、临床分期的上升而降低 ,p16表达阳性者 3a生存率明显高于阴性者 .结论 p16基因在抑制肾盂癌的发生、发展中起重要作用 ,其检测可用于评估肾盂癌的恶性度和预后 .
Objective To study the relationship between the expression of tumor suppressor gene p16 and the pathological grade, clinical stage and prognosis of renal pelvic cancer.Methods The expression of p16 gene in 40 cases of renal pelvic carcinoma was detected by immunohistochemistry.Results The expression of p16 gene in 40 cases of renal pelvic carcinoma Positive rate was 52.5%, the positive rate decreased with the pathological grade and clinical stage of renal pelvis cancer.The survival rate of 3a with p16 positive was significantly higher than that with negative.Conclusion p16 gene can inhibit the occurrence and development of renal pelvic cancer Plays an important role in the detection of renal cell carcinoma can be used to assess the malignancy and prognosis.