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癫痫放电或抗癫痫药(AEDS)可不同程度影响癫痫患者激素水平。痫样放电可直接影响下丘脑-垂体轴(HP轴),影响激素的合成和分泌,尤以性激素和皮质激素明显。AEDS可能直接影响或通过神经递质间接影响HP轴,或通过影响激素的代谢,改变激素的结合蛋白水平以及抑制激素合成等多种机制影响性激素或甲状腺激素水平;但不影响体内基础的皮质激素水平。
Epileptiform discharges or antiepileptic drugs (AEDS) can affect hormone levels in patients with epilepsy to varying degrees. Epileptiform discharge can directly affect the hypothalamus - pituitary axis (HP axis), affecting the synthesis and secretion of hormones, especially sex hormones and corticosteroids. AEDS may directly affect or affect the HP axis indirectly through neurotransmitters, or affect hormones or thyroid hormones through various mechanisms such as affecting hormone metabolism, altering hormone binding protein levels and inhibiting hormone synthesis; however, it does not affect the basal corticosteroids Level.