目的优化阿昔莫司控释片处方。方法以PEG4000的用量和包衣增重为考察因素,应用星点设计-优化面效应法优化阿昔莫司控释片处方。结果优化处方工艺参数为:包衣材料中PEG4000的用量为28.25%,包衣增重7.40%。结论本实验确定的处方方法合理,稳定可行。 Objective To optimize the prescription of acipimox controlled release tablets. Methods The dosage of PEG4000 and the weight gain of coating were taken as the investigation factors. The optimized design of acyclovir controlled release tablets was made by the method of star point design. Results The optimized formulation parameters were as follows: the dosage of PEG4000 in the coating material was 28.25%, and the coating weight was 7.40%. Conclusion The prescription method determined by this experiment is reasonable, stable and feasible.