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目的探讨真菌性阴道炎患者菌种分布及耐药性。方法选取2009年1月至2010年6月我院妇产科住院部及门诊所收集的967份阴道分泌物标本,采用常规涂片法检出83例真菌。在患者的阴道中插入无菌棉拭子,然后将其阴道分泌物置无菌管中送检,采用法国生物梅里埃公司提供的ATB板条进行药敏试验,严格执行说明书的操作步骤。结果本组967份阴道分泌物标本中共检出83株真菌,培养分离出80株真菌,与两性霉素B、制霉菌素相比,唑类药物耐药现象更加严重。结论真菌在菌群失调和机体免疫力降低的环境下往往就会致病,属于一种较为典型的机会性致病菌,应该综合考虑患者的实际病情来选择联合用药还是个体化用药,以此来避免出现耐药菌株。
Objective To investigate the distribution and drug resistance of fungal vaginitis strains. Methods From January 2009 to June 2010, 967 samples of vaginal secretions collected from the obstetrics and gynecology department and outpatient department of our hospital were collected, and 83 cases of fungi were detected by routine smear method. Sterile cotton swabs were inserted into the patient’s vagina and the vaginal secretions were placed in sterile tubes and submitted to drug susceptibility testing using the ATB slats supplied by BioMérieux, France. The procedure for this manual was strictly followed. Results A total of 83 strains of fungi were detected in 967 samples of vaginal secretions from this group, and 80 strains were isolated from fungi. Compared with amphotericin B and nystatin, azole drug resistance was more serious. Conclusions Fungi often cause pathogenicity in the condition of flora imbalance and immunity decrease. It belongs to a kind of typical opportunistic pathogenic bacteria. It should consider the patients’ actual conditions to choose combination therapy or individualized medicine To avoid emergence of drug-resistant strains.