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血管内皮可分泌一些影响血管舒缩的物质如前列环素(PGI_2)、内皮素(ET)等,因此血管内皮可能是激素替代疗法(HRT)的一个靶组织。为测定HRT是否改变血浆和血清调节人血管内皮细胞产生PGI_2和ET-1的能力,选择13例绝经后妇女,绝经时间均≥1年,其卵泡刺激素(FSH)水平均>40mIU/ml,并有明显血管舒缩症状。HRT共包括三个阶段。第一阶段(1～12天),每日口服雌二醇(E_2)
Endothelium can secrete some substances that affect vasomotor, such as prostacyclin (PGI_2) and endothelin (ET). Therefore, vascular endothelium may be a target tissue for hormone replacement therapy (HRT). To determine whether HRT could alter the ability of plasma and serum to regulate the production of PGI_2 and ET-1 in human vascular endothelial cells, 13 postmenopausal women were selected to have a mean of ≥1 year after menopause. The levels of follicle stimulating hormone (FSH)> 40mIU / ml, And obvious vasomotor symptoms. The HRT consists of three phases. The first phase (1 ~ 12 days), daily oral administration of estradiol (E2)