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1.本文观察了15只犬的不同剂量油酸静脉内注射、不同时间活杀和不同处理(治疗与非治疗)的RDS肺脏超微结构变化,发现各组基本病变一致,只不过时间短者病变轻,时间长者病变重。另外,东菪莨碱治疗组与非治疗组病变基本相同,说明该药对本组RDS治疗无效。 2.油酸对肺毛细血管内皮损伤的机制,除其化学毒性作用外,结合毛细血管内中性白细胞集聚,说明补体及中性白细胞产生的毒性氧根亦有作用。 3.本实验所见肺透明膜的成分,有的由血浆蛋白颗粒组成,有的由纤维蛋白组成,透明膜处肺泡上皮未见坏死。关于透明膜的成分,虽然有人提及可由水肿液中的蛋白质沉积于肺泡表面形成,但电镜材料我们所见与文献记载有所不同。 4.本实验见肺泡内有大片表面活性物质存在,且发生空泡化。此现象可能说明RDS时肺泡表面活性物质并不减少,只是因发生了性质的改变而失去了其应有的活性而已。
1. In this study, we observed the ultrastructural changes in RDS lungs of 15 dogs treated with intravenous injection of oleic acid at different doses for different periods of time and killed and treated with different times (treated and non-treated), and found that the basic lesions in each group were the same, Lesions light, the elderly elder times. In addition, the East psoriasis treatment group and non-treatment group of lesions is basically the same, indicating that the drug is ineffective in this group of RDS treatment. 2. The mechanism of oleic acid on pulmonary capillary endothelial injury, in addition to its chemical toxicity, combined with capillary neutrophil accumulation, indicating that complement and neutrophil toxic oxygen root also has a role. In this experiment, the composition of the transparent membrane of the lungs, some by the plasma protein particles, and some by the fibrin composition, transparent membrane at the alveolar epithelial necrosis. As for the composition of the transparent film, although it is mentioned that the protein in the edema fluid can be deposited on the surface of the alveolus, the electron microscopy material we see differs from the literature. 4. In this experiment, there is a large area of alveolar surfactant present, and the occurrence of vacuoles. This phenomenon may indicate that RDS alveolar surfactant does not reduce, but because of the nature of the change has lost its due activity only.