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目的探讨胰腺腺泡细胞癌的临床病理学特点及诊断要点。方法对1例胰腺腺泡细胞癌进行临床资料、病理形态及免疫组化观察,并结合文献对其诊断及鉴别诊断进行探讨。结果镜下穿刺组织中瘤细胞小梁状、微腺样排列;瘤细胞呈圆形或多边形,胞浆丰富,呈嗜酸性颗粒状,部分呈空泡状,核圆形至椭圆形、多位于基底部;间质内见大量嗜酸性粒细胞浸润,胞浆内富含嗜酸性颗粒,细胞核轻度异型。免疫组化染色显示Cg A(-),Ki-67(index约15%)和Syn(-)。结论胰腺腺泡细胞癌比较罕见,提高对其的认识,可避免误诊。
Objective To investigate the clinicopathological features and diagnosis points of pancreatic acinar cell carcinoma. Methods One case of pancreatic acinar cell carcinoma was studied by clinical data, histopathology and immunohistochemistry. The diagnosis and differential diagnosis of pancreatic acinar cell carcinoma were also discussed. Results The tumor cells in the microscopic puncture were arranged in trabecular and micro-adenoids; the tumor cells were round or polygonal with rich cytoplasm, eosinophilic granulocytes and some vacuoles, with a round or oval nucleus, Basal part; see a large number of interstitial eosinophil infiltration, cytoplasm-rich eosinophilic granules, the nucleus mild atypia. Immunohistochemical staining showed Cg A (-), Ki-67 (index about 15%) and Syn (-). Conclusions Pancreatic acinar cell carcinoma is relatively rare, to improve their understanding, to avoid misdiagnosis.