论文部分内容阅读
补体存在于正常动物的血清中,由Nu-ttall(1888)、Buchner(1889)发现,原称杀菌素(alexine),由Ehrlich(1899)改称为补体(complement)。目前发现,补体是由二十多种成分组成的多分子系统,包括各种补体成份、参与旁路活化途径的因子群、各种灭活剂等三大类;补体活化至少有传统(classical)、旁路(alternative)两条途径;补体不仅对抗体有辅助与增强作用,也具有独立的生物学活性。除C(?)q、D 因子、C_3bINA 外,补体系统各成分均以无活性形式(前体分子)存在于血浆中,约占血浆球蛋白总量的10～15%,激活时各成份依次呈链锁样反应活化,参与机体防御、内环境稳定及某些免疫病理过程。
Complement is present in the serum of normal animals and was found by Nu-ttall (1888), Buchner (1889), formerly known as alexine, renamed by Ehrlich (1899) as complement. It has been found that complement is a multi-molecular system composed of more than twenty components, including various complement components, factors involved in the pathway of activation, and various inactivators. Complement activation is at least classical, , Alternative (alternative) two ways; complement not only the auxiliary antibody and enhance the role, but also has independent biological activity. In addition to C (?) Q, D factor, C_3bINA, the components of the complement system are inactive form (precursor molecules) exist in the plasma, accounting for about 10 to 15% of the total plasma globulin, activation of each component in turn Chain-like reaction was activated, involved in body defense, the internal environment and some immune pathological stability.