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人类疾病的本质是遗传因素与环境因素相互作用的结果,遗传因素不仅影响人的体质,也影响疾病的过程和预后。最近几年人们高度重视的主要遗传因素为组织相容性抗原又称为人类白细胞抗原(HLA)。某些疾病检出的HLA位点被认为是该病的编码。国内外已见肾脏疾病与HLA的文献,但未见各临床型和病理型肾小球肾炎HLA检查结果的报道。作者研究肾病型肾小球肾炎(即单纯性微小病变型肾病综合征),间质增殖型肾小球肾炎和膜性增殖型肾小球肾炎的HLA位点分布情况,现将结果报道如下。
The nature of human disease is the result of the interaction of genetic and environmental factors, which not only affect one’s constitution, but also affect the course and prognosis of the disease. In recent years, the main genetic factor that people attach great importance to is the histocompatibility antigen, also known as human leukocyte antigen (HLA). The HLA locus detected for some diseases is considered the code for the disease. Domestic and foreign literature has been seen kidney disease and HLA, but no clinical and pathological glomerulonephritis HLA test results reported. The authors study the nephropathy glomerulonephritis (ie, simplex nephrotic syndrome), interstitial proliferative glomerulonephritis and membranous proliferative glomerulonephritis HLA loci distribution, the results reported below.