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目的:探讨血清血管紧张素转换酶(SACE)活性水平在西宁地区肺部疾病患者中的变化,为病情诊断提供血清学依据。方法:采用奥林匹斯2700型全自动生化分析仪,检测各组患者和健康人员SACE活性。3种肺部疾病[慢性阻塞性肺病(COPD)组、慢性阻塞性肺病急性加重(AECOPD)组、肺源性心脏病(CCP)组]诊断按照2010年国家肺部疾病诊断标准判定,另加健康对照组进行比较,并进行统计学分析。结果:肺部疾病各组SACE活性显著高于健康对照组(P<0.05);慢性阻塞性肺病SACE活性显著高于慢性阻塞性肺病急性加重组(P<0.05),与肺源性心脏病组有显著性差异(P<0.05)。结论:西宁地区SACE活性变化与肺部疾病关系密切,可作为肺部疾病临床鉴别诊断的有效指标。
Objective: To investigate the changes of serum angiotensin-converting enzyme (SACE) activity level in patients with lung disease in Xining area and provide a serological basis for the diagnosis of the disease. Methods: The Olympus 2700 automatic biochemical analyzer was used to detect SACE activity in all patients and healthy individuals. Three kinds of pulmonary diseases [chronic obstructive pulmonary disease (COPD) group, acute exacerbation of chronic obstructive pulmonary disease (AECOPD) group, pulmonary heart disease (CCP) group] were diagnosed according to the 2010 national lung disease diagnostic criteria, plus Healthy control group were compared and statistical analysis. Results: The SACE activity of lung disease group was significantly higher than that of healthy control group (P <0.05). The SACE activity of chronic obstructive pulmonary disease was significantly higher than that of acute exacerbation of chronic obstructive pulmonary disease (P <0.05) There was significant difference (P <0.05). Conclusion: The change of SACE activity in Xining is closely related to lung diseases, which can be used as a valid index in clinical differential diagnosis of lung diseases.