论文部分内容阅读
目的:探究缺血性脑血管病患者高尿酸血症与颅内动脉粥样硬化性狭窄的相关性。方法:对120例缺血性脑血管病患者进行颈部血管彩超检查,同时检测血尿酸、血糖、血脂水平。根据颈部血管彩超结果,分为狭窄组和无狭窄组(对照组),狭窄组再根据其动脉狭窄程度分为轻、中、重度狭窄组,用非条件Logistic回归分析评价颅内动脉粥样硬化性狭窄的相关危险因素,并比较颅内动脉不同狭窄程度间的血尿酸水平。结果:除年龄、高血压、糖尿病、血脂异常等已知危险因素外,高尿酸血症是颅内动脉粥样硬化性狭窄的独立危险因素(OR=2.016,P=0.031)。各组血尿酸水平之间比较差异有统计学意义(P<0.05)。结论:高尿酸血症是颅内动脉粥样硬化性狭窄的独立危险因素,且尿酸水平可提示狭窄的严重程度。
Objective: To investigate the relationship between hyperuricemia and intracranial atherosclerosis in patients with ischemic cerebrovascular disease. Methods: A total of 120 patients with ischemic cerebrovascular disease underwent color Doppler ultrasound examination and blood uric acid, blood glucose and blood lipid levels were measured. According to the results of cervical vascular ultrasound, the patients were divided into the stenosis group and the non-stenosis group (control group). The stenosis group was further divided into mild, moderate and severe stenosis group according to the extent of stenosis. Non-conditional logistic regression analysis was used to evaluate the intracranial atherosclerosis Sclerotic related risk factors, and compare the degree of uric acid between different degrees of intracranial artery stenosis. Results: In addition to the known risk factors such as age, hypertension, diabetes and dyslipidemia, hyperuricemia was an independent risk factor for intracranial atherosclerotic stenosis (OR = 2.016, P = 0.031). The level of serum uric acid in each group was significantly different (P <0.05). Conclusions: Hyperuricemia is an independent risk factor for intracranial atherosclerotic stenosis and uric acid levels may indicate the severity of stenosis.