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本文应用Meta—analysis方法对国内10个有关女性月经、生育因素与乳腺癌关系的病例对照研究进行了定量综合分析。文中介绍了固定效应模型和随机效应模型方法并进行了数据分析。结果无生育者患乳腺癌的综合OR(95％可信限)为1.65(1.26—2.16);初潮年龄越小、月经周期越短、初婚年龄越大、初产年龄越高、生育次数越少、哺乳时间越短患乳腺癌的OR值上升,存在剂量反应关系。另对方法和结果进行了讨论和解释。
Meta-analysis method was used in this paper to conduct a quantitative and comprehensive analysis of 10 case-control studies on the relationship between menstruation, fertility and breast cancer in China. In this paper, the fixed effects model and random effects model methods are introduced and the data are analyzed. Results The comprehensive OR (95% confidence interval) for breast cancer without fertility was 1.65 (1.26-2.16). The shorter the age of menarche, the shorter the menstrual cycle, the higher the age of first marriage, the higher the age of first trimester and the lower the number of births , Breast-feeding shorter breast-feeding OR, there is dose-response relationship. The other methods and results were discussed and explained.