Throughput of mobile ad hoc network (MANET) is limited by collision avoidance. In CDMA-based MANET, this limitation can be overcome by multiuser detection (MUD) because conventional colliding packets can be detached and detected by MUD so that multi-packet reception (MPR) is possible. This paper introduces the principles of MUD algorithm for MANET, and proposes an adaptive blind MUD algorithm. A special medium access control (MAC) protocol is designed to make MANET more efficient. This is achieved by sending more packets to a destination simultaneously. The proposed MUD algorithm and MAC protocol allow CDMA-based MANET to support MPR. Simulations show a remarkable improvement in the throughput performance of MANET.