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目的 分析循环免疫复合物(CIC)在脑梗死发作时的变化及其与近期感染的关系。方法测定46例动脉硬化性脑梗死病例发病初期和恢复期及124例正常对照的CIC、补体Clq、C3,脑梗死组病例做发病初期和恢复期的先后比较,同时与正常对照测定值比较。结果 脑梗死组发病初期CIC测定值(16.47±12.46mg/dl),高于正常对照组(6.70±4.27mg/dl,P<0.01),井在恢复期下降,Clq发病初期(0.14±0.04g/L)低于恢复期(0.17±0.04g/L,P<0.05)并低于正常对照(0.20±0.04g/L),C3(1.16±0.06g/L)低于正常对照组(1.71±0.57g/L)且先后两期测定变化无差异。按有/无感染史分两组比较,有感染史组梗死初期CIC高于无感染史组并持续到恢复期,Clq测定值两组均偏低,并在恢复期回升明显,有感染史组C3高于无感染史组,回升不明显。CIC与梗死的最大直径和面积呈一定正相关。结论 CIC升高可能与感染有关,梗死初期CIC与脑梗死损伤程度呈一定正相关。
Objective To analyze the changes of circulating immune complex (CIC) during the onset of cerebral infarction and its relationship with recent infection. Methods 46 patients with arteriosclerotic cerebral infarction at onset and recovery and 124 normal control CIC, complement Clq, C3, cerebral infarction group of patients at the onset and recovery of the first comparison, and compared with the normal control values. Results In the early stage of cerebral infarction, the CIC value (16.47 ± 12.46 mg / dl) was higher than that of the normal control group (6.70 ± 4.27 mg / dl, P <0.01) / L) was significantly lower than that of the control group (0.17 ± 0.04g / L, P <0.05) and lower than that of the normal control group (0.20 ± 0.04g / L) 0.57g / L) and no difference between the two measured changes. According to the presence / absence of infection, there was no difference between the two groups. The CIC in the history of infection in the history of infection was higher than that in the history without infection and continued until the recovery. The Clq values were both lower and recovered significantly during the recovery period. C3 higher than non-infected history group, the rise is not obvious. CIC had a positive correlation with the maximum diameter and area of infarction. Conclusions The elevated CIC may be related to infection. There is a positive correlation between CIC and the severity of cerebral infarction in the early stage of infarction.