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目的观察γ-干扰素(IFN-γ)联合口服激素治疗特发性肺间质纤维化患者(IPF)的疗效。方法将56例IPF患者随机分为口服激素治疗组和IFN-γ联合口服激素治疗组,测定IPF患者治疗前后血清IFN-γ、白细胞介素-4(IL-4)、Ⅲ型胶原(Ⅲ-C)、Ⅳ型胶原(Ⅳ-C)、基质金属蛋白酶2(MMP-2)的含量变化及临床症状、肺CT、肺弥散功能的变化。结果两组患者治疗后患者临床症状及辅助检查指标均较治疗前好转(P﹤0.05),IFN-γ联合口服激素治疗组疗效优于口服激素治疗组(P﹤0.05)。结论在口服激素基础上加用IFN-γ治疗IPF,恢复Thl/Th2比值平衡,可以更好地改善患者临床症状及肺纤维化程度。
Objective To observe the efficacy of interferon-γ (IFN-γ) combined with oral hormones in the treatment of patients with idiopathic pulmonary fibrosis (IPF). Methods Fifty-six patients with IPF were randomly divided into oral hormone treatment group and IFN-γ combined with oral hormone treatment group. The serum levels of IFN-γ, IL-4 and Ⅲ- C), type Ⅳ collagen (Ⅳ-C), matrix metalloproteinase-2 (MMP-2) content and clinical symptoms, pulmonary CT, pulmonary diffuse function changes. Results The clinical symptoms and the auxiliary examination indexes of the two groups were better than those before treatment (P <0.05). The effect of IFN-γ combined with oral hormone treatment group was better than that of oral hormone treatment group (P <0.05). Conclusions The combination of oral hormones with IFN-γ treatment of IPF and restore the balance of Thl / Th2 ratio, can better improve the clinical symptoms and pulmonary fibrosis in patients.