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本文对135例胃癌患者末梢血淋巴细胞中的嘌呤核苷磷酸化酶(PNP)活性进行了测定。PNP 是一种与免疫机能有关的重要酶类。先天性免疫缺陷症(特别是 T 细胞功能缺陷)的患者往往缺乏这种酶。作者对胃癌患者术前、术后3周和3个月的 PNP 水平及其它免疫学指标进行了测定。结果表明,(1)胃癌患者的 PNP 活性随其病程进展而上升;(2)术后3周无论何期胃癌,其 PNP 活性与术前相比明显增高。而术后3个月患者 PNP 活性有回复至术前水平的倾向;(3)其它免疫学指标(PHA,PPD,皮内试验,淋巴细胞转化试验)随病程进展而表现为反应性低下。术后3
In this paper, the purine nucleoside phosphorylase (PNP) activity in peripheral blood lymphocytes of 135 patients with gastric cancer was measured. PNP is an important enzyme involved in immune function. People with congenital immunodeficiency (especially T cell dysfunction) often lack this enzyme. The authors measured PNP levels and other immunological parameters before, after, and 3 and 3 months after surgery in patients with gastric cancer. The results showed that (1) PNP activity in gastric cancer patients increased as the disease progressed; (2) PNP activity was significantly higher than that before surgery in patients with gastric cancer no matter what period of time after surgery. At 3 months postoperatively, PNP activity reverted to preoperative levels; (3) Other immunological parameters (PHA, PPD, intradermal, lymphocyte transformation tests) showed poor responsiveness as the disease progressed. Postoperative 3