心衰患者对扩血管药治疗的反应因病理生理情况不同而异。大量证据表明,影响患者对扩血管药治疗反应的因素是多方面的。本文从扩血管药的血管作用、外周血管舒张引起的内源性神经-体液反应、左心室对外周血管舒张的反应以及外周血流局部分布的变化等四方面对此进行了简单的讨论。 The response of patients with heart failure to vasodilator therapy varies depending on the pathophysiology. There is ample evidence that there are many factors that influence the response of patients to vasodilators. This article briefly discusses the vasoactive effects of vasodilators, the intrinsic neuro-humoral responses to peripheral vasodilatation, the responses of left ventricle to peripheral vasodilation, and the changes of local distribution of peripheral blood flow.