糖尿病常伴有慢性神经及心血管系统、微血管及大血管病变。心血管系统病变据报导,占糖尿病死亡率达75％以上;而糖尿病合并心血管病变中伴有高血压病者,约占糖尿病合并症之30～40％。肾素—血管紧张素系统(R—AT),在血压调节方面的作用,已日益为人们所关注。自1973年 Diabetes often accompanied by chronic nerve and cardiovascular system, microvascular and macrovascular disease. Cardiovascular disease According to reports, accounting for diabetes mortality rate of 75% or more; and diabetes associated with cardiovascular disease associated with hypertension, accounting for about 30 to 40% of diabetic complications. The role of the renin-angiotensin system (R-AT) in blood pressure regulation has drawn increasing attention. Since 1973