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探讨急性脑血管病（ＡＣＶＤ）时体内免疫状态的变化。对５１例ＡＣＶＤ患者应用酶联免疫吸附分析（ＥＬＩＳＡ）法进行血清肿瘤坏死因子α（ＴＮＦα）和可溶性白细胞介素２受体α（ｓＩＬ２Ｒα）测定。结果：ＡＣＶＤ急性期血清ＴＮＦα和ｓＩＬ２Ｒα水平均明显高于正常对照组（Ｐ均＜０．００１），其中重度组ＴＮＦα水平高于轻度组（Ｐ＜０．０５）；恢复期血清的ＴＮＦα和ｓＩＬ２Ｒα水平虽有所下降，但仍高于正常对照组（Ｐ＜０．０５和Ｐ＜０．００１）。表明单核巨噬细胞和Ｔ细胞的免疫功能状态与ＡＣＶＤ的发病有一定的关系。
To investigate the changes of immune status in patients with acute cerebrovascular disease (ACVD). Serum levels of tumor necrosis factor α (TNFα) and soluble interleukin 2 receptor α (sIL2Rα) were measured by enzyme linked immunosorbent assay (ELISA) in 51 patients with ACVD. Results: Serum levels of TNFα and sIL2Rα in acute phase of ACVD were significantly higher than those in normal control group (all P <0.001), and the level of TNFα in severe group was higher than that in mild group (P <0.05) Although sIL2Rα level decreased, it was still higher than that of the normal control group (P <0.05 and P <0.001). The results showed that the immune function of mononuclear macrophages and T cells was related to the pathogenesis of ACVD.