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在二氯甲烷溶液中,在三氯化铝存在下,2.3-二氢-1H-环庚[b]吡嗪与等摩尔的乙酰氯,丙酰氯、苯甲酰氯相作用生成相应的2-(2-酰氨基已基氨基)酮.当用2克分子丁酰氯则生成2-(2-丁酰氨基乙基氨基)酮和2—[(2-丁酰氨基乙基)(丁酰基)氨基]酮.
Reaction of 2.3-dihydro-1H-cyclohepta [b] pyrazine with equimolar acetyl chloride, propionyl chloride, benzoyl chloride in the presence of aluminum trichloride in methylene chloride yields the corresponding 2 - (2-amidocaproylamino) ketone. 2- (2-butyrylaminoethylamino) ketone and 2 - [(2-butyrylaminoethyl) (butyryl) amino] ketone are formed when 2 moles of butyryl chloride are used.