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间置于动脉的移植静脉段可发生管壁增厚、纤维形成及内膜下肌细胞增生等一系列形态学的改变,从而成为适应动脉内腔高压的有效血管通道,该现象称为静脉管壁“动脉化”。至于移入的静脉有否功能上适应性改变,即内皮细胞(EC)的PGI_2变化,尚不清楚。已知同种静脉移植会产生EC的免疫性损伤,但其PGI_2的改变尚无研究。本文介绍自体,同种V-A移植后管腔内表面不同时间的形态和生化变化,并与正常动、静脉的PGI_2相比较。实验犬29条,取两侧股静脉各8cm,作自体和同种颈、股动脉间置移植。另15条犬颈、股动静脉作为PGI_2检查的正常对照。术后分别于1～2周、4～6周和10～12周切取移植段静脉作光学、电子显微镜观察
Intervenient septal artery graft can occur a series of morphological changes such as wall thickening, fibrosis and submucous myocyte proliferation, and thus become effective vascular access to arterial hypertension, a phenomenon known as intravenous Wall “Arterial.” It is unclear whether there is a functionally adaptive change in the infused vein, ie, changes in PGI2 in endothelial cells (ECs). It is known that the same kind of vein graft produces immune damage of EC, but there is no research on the change of PGI2. This article describes the morphological and biochemical changes of the lumen surface at different times after autologous and allogeneic V-A transplantation and compared with the normal arterial and venous PGI_2. Experimental dogs 29, take both sides of the femoral vein 8cm, for autologous and allogenic neck, femoral artery intercostal transplantation. Another 15 canine neck, femoral artery and vein as PGI_2 check the normal control. The grafts were cut off at 1 ~ 2 weeks, 4 ~ 6 weeks and 10 ~ 12 weeks respectively for optical and electron microscopy