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为探讨GDC(电解可脱弹簧圈)或CAP(纤维素醋酸盐聚合物)对实验性动脉瘤的治疗效果和组织学变化。本文作者将14只杂种狗11～18kg,切取6cm的颈外静脉每5mm一段,一端结扎,一端缝合在颈动脉上制成13个末端动脉瘤和30个侧壁动脉瘤。2周后对狗行造影检查并随机分组。对照组(n=4);GDC栓塞治疗组(n=4),经股动脉穿刺将5F导管送到颈动脉近端,用Track18送入GDC进行治疗,治疗过程中用肝素盐水持续冲洗(1000u/1);CAP治疗组(n=6),先置7F导引导管,然后用Track18经导引导管送入动脉瘤,同样用肝素生理盐水冲洗,再行对侧穿刺插管将球囊送到动脉瘤颈部,充盈球囊,动脉瘤内注入造影剂估计体积后,用250mgCAP+3ml二甲基亚砜+90mg三氧化铋(不透X线)混合后注入相应的体积,停留5～10分钟,萎陷球囊后与微导管一起拔出。2个月后行造影检查,再将狗放血处死,仔细解剖取出动脉瘤用10％福尔马林固定,剖开摄像,全面记录,然后再将脑组织取出用10％福尔马林固定,脱水,包埋,切片,分别在
To investigate the therapeutic effect and histological changes of experimental aneurysms with GDC (Electrolytic Detachable Coil) or CAP (cellulose acetate polymer). The author of this study will 14 hybrid dogs 11 ~ 18kg, cut 6cm jugular vein every 5mm section, one end ligation, one end sutured in the carotid artery made of 13 end aneurysms and 30 sidewall aneurysms. Two weeks later, the dogs were examined by radiography and randomly divided into groups. The control group (n = 4); GDC embolization group (n = 4). The 5F catheter was delivered to the proximal part of the carotid artery via femoral artery puncture. The wounds were treated with GDN for Track18 and continuously rinsed with heparin saline / 1); CAP treatment group (n = 6), the first set of 7F guide catheter, and then guided by Track18 catheter into the aneurysm, also with heparin saline flushing, To the aneurysm neck, filling the balloon, aneurysm injection of contrast agent estimated volume, with 250mgCAP +3 ml dimethyl sulfoxide + 90mg bismuth oxide (opaque X-ray) mixed into the corresponding volume, stay 5 ~ After 10 minutes, the balloon collapses with the microcatheter. 2 months after the line angiography, and then the dog bleeding, carefully dissect the aneurysm removed with 10% formalin fixed, cut open the camera, a comprehensive record, and then remove the brain tissue with 10% formalin fixed, Dehydrated, embedded, sliced, respectively