论文部分内容阅读
了解慢性肾小球疾病患者血浆降钙素基因相关肽(CGRP)和内皮素(ET)的意义。采用放免法测定100例不同临床表现患者血浆CGRP和ET水平,19例正常人作为对照。结果慢性肾衰和各种表现的肾炎患者CGRP均显著降低,ET/CGRP比值显著增高,肾病综合征患者CGRP降低较为显著,肾衰患者ET显著高于肾功能正常者。在肾功正常的肾炎患者中,高血压与血压正常者之间血浆CGRP和ET均无显著差异。在肾衰患者中高血压者ET则显著高于血压正常者,血液透析者ET显著高于非透析者,前者在透析后CGRP水平显著增高,ET显著降低,ET降低值与CGRP增加值呈显著正相关。CGRP和ET可能参与慢性肾脏疾病的发病。
To understand the significance of plasma calcitonin gene-related peptide (CGRP) and endothelin (ET) in patients with chronic glomerular disease. The plasma levels of CGRP and ET in 100 patients with different clinical manifestations were measured by radioimmunoassay, and 19 normal controls were used as controls. Results The patients with chronic renal failure and various manifestations of glomerulonephritis had significantly lower CGRP, higher ET / CGRP ratio, more significant reduction of CGRP in nephrotic syndrome patients, and significantly higher ET in patients with renal failure than those with normal renal function. Nephropathy in patients with normal nephritis, hypertension and normotension between plasma CGRP and ET no significant difference. The ET in hypertensive patients with renal failure was significantly higher than those with normal blood pressure, hemodialysis ET was significantly higher than non-dialysis patients, the former after dialysis CGRP levels were significantly increased, ET was significantly lower, ET decreased and CGRP increased significantly positive Related. CGRP and ET may be involved in the pathogenesis of chronic kidney disease.