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应用免疫组织化学方法研究25例阴茎癌组织中增殖细胞核抗原(PCNA)和表皮生长因子受体(EGFR)的表达水平。结果发现在表达阳性的PCNA和EGFR分别定位于肿瘤细胞核内和细胞膜上,25例阴茎癌组织中PCNA阳性检出率为80%(20/25),EGFR为56%(14/25)。并且PCNA和EGFR阳性表达率与用茎癌的病理分级和临床分期关系密切。提示PCNA和EGFR免疫学指标可评估阴茎癌的预后。
Immunohistochemistry was used to study the expression of proliferating cell nuclear antigen (PCNA) and epidermal growth factor receptor (EGFR) in 25 cases of penile cancer. The results showed that PCNA and EGFR were positively localized in the nucleus and on the cell membrane respectively. The positive rate of PCNA was 80% (20/25) and the EGFR was 56% (14/25) in 25 cases of penile cancer. And the positive expression rate of PCNA and EGFR was closely related to the pathological grading and clinical stage of the carcinoma. Tip PCNA and EGFR immunological indicators can assess the prognosis of penile cancer.