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建立昆明系成鼠动物模型，对肾综合征出血热亚中和水平抗体增强病毒感染作用进行研究。用 Ｒ２２ 、 Ａ１６ 株病毒分别免疫小鼠，制备免疫血清，检测免疫血清中和抗体效价。实验组小鼠脑内感染１０５ Ｌ Ｄ５０（００３ｍｌ） 不同毒株悬液，小鼠染毒前２４ｈ 、１ｈ 或染毒后２４ｈ 、４８ｈ ，经ｉｖ 被动输入同型免疫血清，对照组小鼠输入０１０ｍｌ 的正常鼠血清。感染病毒后经腹腔注射环磷酰胺５０ｍｇ／ｋｇ 。小鼠被动输入小剂量免疫血清，病毒感染力增强，表现为潜伏期缩短，起病急，死亡迅速。输入０２０ ｍｌ 免疫血清小鼠保护率为２２２ ％ （２／９） ，输入０８０ ｍｌ 免疫血清小鼠保护率达１００ ％ （１０／１０） 。
Kunming mouse model was established to study the effect of sub-neutralizing antibody of hemorrhagic fever with renal syndrome on enhancing virus infection. The mice were respectively immunized with R22 and A16 viruses to prepare immune sera, and the antibody titers of the neutralizing antibodies in immune sera were measured. In experimental group, the mice were infected with 105 L D50 (003 ml) different virus suspension in the brain of mice in the experimental group. The mice were injected with the same type of immune serum at 24h, 1h or 24h and 48h after exposure. 0 10ml of normal rat serum. Cyclophosphamide 50mg / kg was injected intraperitoneally after infecting the virus. Mice passive input of small doses of immune serum, enhanced viral infectivity, manifested as shortening the incubation period, acute onset, rapid death. The protection rate of 020 ml immune serum mice was 222% (2/9), and the protection rate of mice fed 080 ml immune serum was 100% (10/10).