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:【目的】研究胰岛素依赖型糖尿病 (IDDM)型牙周病患者龈沟液前列腺素E2 水平及其与糖代谢状况的关系。【方法】以 2 8例IDDM型牙周病患者及 5 4例全身健康的牙周病人为研究对象 ,利用放射免疫法测龈沟液前列腺素E2 水平 ,同时测IDDM病人糖化血红蛋白浓度。【结果】当牙周病严重度相同时 ,IDDM患者龈沟液前列腺素E2 水平 (μg/L)明显高于全身健康者 (186± 5 3vs46± 7,346± 2 8vs48± 10 ,P <0 0 1)。糖尿病人中 ,中重度牙周炎值几乎为轻度牙周病的两倍。龈沟液前列腺素E2 水平与糖化血红蛋白浓度无相关性。【结论】IDDM病人龈沟液前列腺素E2 增高可能因全身反应异常所致 ,这一介质水平的上升 ,反过来会进一步促进牙周病变发展
: 【Objective】 To investigate the relationship between gingival crevicular fluid prostaglandin E2 level and glucose metabolism in patients with insulin-dependent diabetes mellitus (IDDM) type periodontal disease. 【Methods】 A total of 28 patients with periodontal disease and 54 healthy periodontal patients were enrolled in this study. The levels of prostaglandin E2 in gingival crevicular fluid were measured by radioimmunoassay. The concentrations of glycated hemoglobin in patients with IDDM were also measured. 【Results】 When the severity of periodontal disease was the same, the level of prostaglandin E2 (μg / L) in gingival crevicular fluid of IDDM patients was significantly higher than that of healthy controls (186 ± 5 3 vs 46 ± 7, 346 ± 2 8 vs 48 ± 10, P <0.01 ). Diabetic patients, moderate to severe periodontitis value is almost twice as mild periodontal disease. Gingival crevicular fluid prostaglandin E2 levels and glycosylated hemoglobin concentration no correlation. 【Conclusion】 The increase of prostaglandin E2 in gingival crevicular fluid of IDDM patients may be caused by abnormalities of systemic reaction. The increase of this medium level will in turn promote the development of periodontal disease