论文部分内容阅读
双侧卵巢切除术是绝经前期晚期乳腺癌常用的治疗方法。手术切除卵巢后可以降低或阻断雌激素对肿瘤的作用,从而使肿瘤退缩。去除卵巢的方法有手术切除或放射去势2种,手木切除卵巢的治疗作用发生较快,放射治疗在照射达16-20 Gy后亦能获得同样效果,从治疗到发生作用常需要较长时间。但是,目前乳腺癌手术后作预防性卵巢切除的疗效尚有争议。T8ylor 1934年首次报道乳腺癌根治木后用放射疗法去除卵巢与对照组(单纯乳腺癌根治术)的4年生存率元差别,以后很多研究报道预防性切除卵巢可推迟术后复发的时间,尤其是对淋巳结有转移的病例,但总的生存率并不提高。对预防性切除卵巢目前的争议主要在于切除卵是否延长生存期,以及预防性切除卵巢的适应症、切除时机与绝经的关系等。为了能够正确地选择适当的治疗方法,我们摘译了C。hrane图书馆中“卵巢切除术治疗早期乳腺癌的系统评价”文献,以供临床医生参考。
Bilateral ovariectomy is a commonly used treatment for advanced premenopausal women with breast cancer. Surgical removal of the ovary can reduce or block the role of estrogen on the tumor, so that the tumor shrinks. Ovariectomy or surgery to remove the castration of 2 kinds of hand wood removal of the ovary treatment occurs faster, radiation therapy in the irradiation up to 16-20 Gy after the same effect can be obtained from the treatment to the role of often require a longer time. However, the efficacy of prophylactic ovariectomy after breast cancer surgery is controversial. T8ylor first reported in 1934 after radical mastectomy of breast cancer with radiotherapy to remove the ovary and control group (simple radical mastectomy) 4-year survival rate differences, many studies have reported since the prevention of ovarian resection may postpone the time of recurrence, especially Is lymph node metastasis cases, but the overall survival rate does not increase. The current controversial prophylaxis of ovariectomized ovarian cancer is mainly whether the excision of the ovary prolongs the survival period, as well as the indications of prophylactic ovariectomy, the timing of resection and the relationship between menopause and so on. In order to be able to properly select the appropriate treatment, we have translated C. hrane Library “ovariectomy for the treatment of early breast cancer,” the literature for clinicians reference.