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应用流式细胞术和免疫荧光染色技术对３１例白血病及９例营养性贫血（ＮＤＡ）患者骨髓细胞Ｐ１６蛋白进行检测。结果显示急性淋巴细胞白血病组（ＡＬＬ）Ｐ１６阳性率６３２％，急性非淋巴细胞白血病组（ＡＮＬ）８３３％，营养性贫血组８８９％。ＡＬＬ组Ｐ１６阳性率与ＡＮＬ组相比，差异有显著性（Ｐ＜００１）；与营养性贫血组相比，亦有显著性（Ｐ＜００１）。ＡＮＬ组Ｐ１６阳性率与营养性贫血组相比，差异无显著性（Ｐ＞００５）。提示Ｐ１６基因的改变与淋巴系白血病的发生有密切关系。
Flow cytometry and immunofluorescence staining were used to detect P16 protein in bone marrow cells in 31 patients with leukemia and 9 patients with nutritional anemia (NDA). The results showed that the positive rate of P16 was 63. 2% in acute lymphoblastic leukemia (ALL), 83. 3% in acute non-lymphocytic leukemia (ANL), and 88.9% in nutritional anemia. The positive rate of P16 in ALL group was significantly higher than that in ANL group (P<001). Compared with nutritional anemia group, there was also significant difference (P<001). There was no significant difference in the positive rate of P16 between the ANL group and the nutritional anemia group (P>005). It suggests that the change of P16 gene is closely related to the occurrence of lymphoid leukemia.