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本文应用动物诱癌试验观察内源性和外源性表皮生长因子（EGF）对二甲基肼（DMH）诱发WISTAR鼠大肠癌效力的影响。将60只大白鼠随机分咸四组：高EGF组、普通组（对照组）、低EGF组、单EGF组、用DMH连续诱癌20周。结果发现高EGF组动物诱癌阳性率、平均负瘤数、肿瘤平均体积均明显高于普通组，更高于低EGF组（P＜0．05），单EGF组无肿瘤产生。提示EGF可增强DMH诱发WISTRR鼠大肠癌的效力，但不能独立致癌，在本实验中EGF有类似促癌剂的作用。
In this article, we used animal carcinogenesis assay to observe the effect of endogenous and exogenous epidermal growth factor (EGF) on the efficacy of dimethyl hydrazine (DMH)-induced colorectal cancer in Wistar mice. Sixty rats were randomly divided into four groups: high EGF group, normal group (control group), low EGF group, single EGF group, and continuous induction of cancer with DMH for 20 weeks. The results showed that the positive rate of cancer induction, the average number of negative tumors, and the average volume of tumors in the high EGF group were significantly higher than those in the normal group and higher than in the low EGF group (P<0.05). No tumor was generated in the single EGF group. It suggests that EGF can enhance the efficacy of DMH-induced WISTRR murine colon cancer, but it cannot independently cause cancer. In this experiment, EGF has a similar effect as a carcinogen.