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目的探讨脂肪肝患者代谢异常与肝脏损伤程度的关系。方法资料来源于2006年5月至2008年12月安徽医科大学第一附属医院健康体检资料,将研究对象分为非脂肪肝组、脂肪肝丙氨酸转氨酶(ALT)正常组、脂肪肝ALT升高小于2倍上限组和脂肪肝ALT升高大于2倍上限组。分别比较其血糖、血脂、尿酸水平以及高血压、高血糖、高甘油三酯血症、高胆固醇血症和高尿酸血症的患病率差异。结果脂肪肝患者空腹血糖浓度随ALT升高而升高;尿酸浓度、高血压的患病率在不同ALT浓度组间差异无统计学意义;在血脂代谢方面,ALT异常的男性脂肪肝患者血甘油三酯和总胆固醇的浓度较ALT正常患者高,但ALT 2倍以上升高和2倍以下升高组间差异无统计学意义。ALT异常的女性患者血甘油三酯和总胆固醇浓度未见明显升高,且总胆固醇浓度在ALT升高大于2倍上限组出现了显著降低。结论脂肪肝患者肝功能损害程度与血糖密切相关,而与血甘油三酯、血胆固醇、血尿酸及高血压关系不大。
Objective To investigate the relationship between metabolic abnormalities and liver damage in patients with fatty liver. Methods The data were from the physical examination data of the First Affiliated Hospital of Anhui Medical University from May 2006 to December 2008, and the subjects were divided into non-fatty liver group, normal ALT group, ALT Higher than 2 times the upper limit of the group and fatty liver ALT increased more than 2 times the upper limit of the group. The prevalence of hyperglycemia, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia and hyperuricaemia were compared respectively with their blood glucose, blood lipids and uric acid levels. Results The fasting blood glucose level increased with the increase of ALT in patients with fatty liver. The prevalence of uric acid and hypertension was not significantly different between different ALT groups. In terms of blood lipid metabolism, Triethanolamine and total cholesterol concentrations were higher than those with normal ALT, but there was no significant difference between the groups with two-fold ALT and two-fold higher ALT levels. In women with ALT abnormalities, there was no significant increase in triglyceride and total cholesterol levels, and total cholesterol levels decreased significantly in the group with an ALT greater than 2-fold upper limit. Conclusion The degree of liver dysfunction in patients with fatty liver is closely related to blood glucose, but not to triglyceride, blood cholesterol, blood uric acid and hypertension.