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目的 :探讨营养不良、肾病本身和糖皮质激素对大鼠生长、食物效率及血清GH浓度的影响。方法 :2 4只周龄相同体重相近的雄性SD大鼠被随机分成正常、食物对照、阿霉素 (5mg/kg)肾病和地塞米松 (1.8mg/kg·d)治疗肾病四组。按常规测量摄食量、体重、鼻 -尾长度和血清GH浓度 ,计算生长速率和食物效率并进行比较。结果 :肾病组大鼠摄食量低于正常组 ,激素治疗组低于肾病组。肾病组大鼠生长速率和食物效率均低于食物对照组 ,激素治疗组低于肾病组 ,但食物对照组除生长速率低于正常组外 ,食物效率两组相同 ;食物对照组大鼠血清GH浓度增高 ,肾病组正常 ,激素治疗组低于肾病组。结论 :除继发性营养不良和糖皮质激素治疗外 ,肾病本身也是引发NS生长障碍的重要因素 ;仅有糖皮质激素治疗可能部分通过影响血清GH浓度参与NS生长障碍的发病过程
Objective: To investigate the effects of malnutrition, nephrosis and glucocorticoids on growth, food efficiency and serum GH concentration in rats. Methods: Forty four male Sprague-Dawley rats of the same body weight were randomly divided into four groups: normal control group, adriamycin (5mg / kg) nephropathy and dexamethasone (1.8mg / kg · d) The food intake, body weight, nose-tail length and serum GH concentration were routinely measured, and the growth rate and food efficiency were calculated and compared. Results: The food intake of rats in nephropathy group was lower than that of normal group, and that of hormone treatment group was lower than that of nephrosis group. Nephrosis group rats growth rate and food efficiency were lower than the food control group, hormone treatment group than the nephropathy group, but the food control group except growth rate lower than the normal group, the food efficiency of the two groups; food control group serum GH Increased concentration, normal renal disease group, hormone therapy group was lower than the nephropathy group. CONCLUSIONS: In addition to secondary malnutrition and glucocorticoid therapy, nephropathy is itself an important factor in triggering NS growth disorders; only glucocorticoid therapy may be partially involved in the pathogenesis of NS growth disorders by affecting serum GH concentrations