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目的探讨能有效降低高危急性早幼粒细胞白血病(APL)早期病死率、减少血液和髓外复发的合理治疗方法。方法对APL初诊时高白细胞与非高白细胞患者的临床生物学特征及治疗转归进行回顾性分析和比较。结果29例初诊高白细胞的APL患者占131例初治APL的22.0%,其细颗粒型和CD34~+表达显著增多,早期病死率和复发率亦高于初治白细胞不高的患者。结论初诊高白细胞的APL为高危患者,治疗应个体化,尽早化疗。
Objective To explore a reasonable treatment method that can effectively reduce the early mortality of high-risk acute promyelocytic leukemia (APL) and reduce the blood and extramedullary recurrence. Methods The clinical features and prognosis of patients with high white blood cells and non-high white blood cells in newly diagnosed APL patients were retrospectively analyzed and compared. Results The APL patients with 29 newly diagnosed high white blood cells accounted for 22.0% of the 131 newly diagnosed APL patients. The expression of fine granule and CD34 ~ + was significantly increased, and the early mortality and recurrence rate were also higher than those of the untreated leucocytes. Conclusions APL of newly diagnosed high white blood cells is a high-risk patient. Treatment should be individualized and chemotherapy should be performed as soon as possible.